µsmin®Plus (Microsmin Plus)

Innovative diosmin formulation featuring dramatically enhanced absorption and bioavailability.


Diosmin, a citrus flavonoid derived from hesperidin, has a long history of use as a vascular protecting compound primarily for the management of chronic venous insufficiency (CVI), hemorrhoids, varicose veins, and lymphedema.

Active: diosmin (NLT 80% by HPLC)

Extract Type: granular powder

Recommended Dosage: 570 mg 

Applications: powders, tablets, hard shell capsules

USP and features

  • Superior alternative to the standard form of diosmin currently sold in the market
  • Pre-clinical and clinical bioavailability studies (published)
  • Efficacy human clinical trial (published)
  • 9x increased bioavailability vs standard micronized diosmin, after oral supplementation
  • Great flowability and compressibility
  • Residual solvents < 1 ppm

Scientific evidence/Proprietary studies

Pharmacokinetic profile of µsmin® Plus (Microsmin Plus), a new micronized diosmin formulation, after oral administration in rats (Russo et al 2015). Comparative Bioavailability of Two Diosmin Formulations after Oral Administration to Healthy Volunteers (Russo et al 2018). Efficacy of a Low‐Dose Diosmin Therapy on Improving Symptoms and Quality of Life in Patients with Chronic Venous Disease: Randomized, Double‐Blind, Placebo‐Controlled Trial (Serra et al 2021).

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