µsmin® Plus (Microsmin® Plus) from Giellepi is an innovative diosmin-based ingredient formulated to address the needs of consumers who want to support the challenged circulation in legs in a convenient once per day dose.

Diosmin (3’, 5, 7-trihydroxy-4’-methoxyflavone-7-rhamnoglucoside), a natural occurring flavonoid present in citrus fruits and commonly manufactured from hesperidin found in bitter and sweet orange has poor absorption with large doses of powder typically needed for health benefits.

Microsmin® Plus has been designed to get in the system quickly showing 9.4 times greater bioavailability compared to micronized diosmin. Its ability to promote leg vein health benefits has been demonstrated by an 8-week randomized, double-blind, placebo-controlled trial including both men and women.

µsmin® Plus

Diosmin (NLT 80% by HPLC)

Granular powder

Recommended daily dosage:
570 mg

Tablets, capsules, powders (for oral suspension)


µsmin® Plus SG

Diosmin (NLT 83% by HPLC)

Micronized powder

Recommended daily dosage:
550 mg

Softgels and gummies


μsmin® Plus is produced using a proprietary technology that allows to achieve the optimal concentration threshold of diosmin’s bioactive form while limiting the presence of selected extraction solvents below 1 ppm. Getting more of the active form means less dosage required needed for health benefits and more formulation flexibility.


  • Painful, tired and heavy legs
  • Swollen legs
  • Discomfort, prickly sensation, heat/burning feeling, night-time cramps
  • Spider veins

Clinical evidence

A double-blind, two-period, cross-over trial in healthy subjects showed 9.4 times greater relative absorption of μsmin® Plus than standard micronized diosmin (Russo et al. 2018). Due to its better rate, μsmin® Plus has been evaluated in a double-blind, randomized, placebo-controlled clinical study on subjects suffering from poor blood circulations in the legs to assess its benefits on typical signs and symptoms (swelling, heaviness, pain…) and quality of life.


1. Less swelling with reduction of calf circumference

2. Less leg soreness

3. Better Quality of Life

Russo et at. Natural Product Communications 2015, 10 (9)
Russo et al. Molecules 2018, 23, 2174
Serra et al. Nutrients 2021, 13, 999

Giellepi solutions

Our legacy of expertise and innovation drives us to create nutritional solutions to support healthy lifestyles.