μsmin® Plus is a breakthrough diosmin-based ingredient that is specifically validated to support tired and heavy legs that can result from aging and normal everyday conditions while promoting leg vein health and appearance.
µsmin® Plus (Microsmin® Plus) from Giellepi is an innovative diosmin-based ingredient formulated to address the needs of consumers who want to support the challenged circulation in legs in a convenient once per day dose.
Diosmin (3’, 5, 7-trihydroxy-4’-methoxyflavone-7-rhamnoglucoside), a natural occurring flavonoid present in citrus fruits and commonly manufactured from hesperidin found in bitter and sweet orange has poor absorption with large doses of powder typically needed for health benefits.
Microsmin® Plus has been designed to get in the system quickly showing 9.4 times greater bioavailability compared to micronized diosmin. Its ability to promote leg vein health benefits has been demonstrated by an 8-week randomized, double-blind, placebo-controlled trial including both men and women.
Diosmin (NLT 80% by HPLC)
Recommended daily dosage:
Tablets, capsules, powders (for oral suspension)
Dramatic improvement in leg discomfort and quality of life.
Supported by 1 preclinical and 2 human clinical trials.
Works with a lower daily dose than micronized diosmin.
Optimized flowability and compressibility.
μsmin® Plus is produced using a proprietary technology that allows to achieve the optimal concentration threshold of diosmin’s bioactive form while limiting the presence of selected extraction solvents below 1 ppm. Getting more of the active form means less dosage required needed for health benefits and more formulation flexibility.
- Painful, tired and heavy legs
- Swollen legs
- Discomfort, prickly sensation, heat/burning feeling, night-time cramps
- Spider veins
A double-blind, two-period, cross-over trial in healthy subjects showed 9.4 times greater relative absorption of μsmin® Plus than standard micronized diosmin (Russo et al. 2018). Due to its better rate, μsmin® Plus has been evaluated in a double-blind, randomized, placebo-controlled clinical study on subjects suffering from poor blood circulations in the legs to assess its benefits on typical signs and symptoms (swelling, heaviness, pain…) and quality of life.
1. Less swelling with reduction of calf circumference
2. Less leg soreness
3. Better Quality of Life
Russo et at. Natural Product Communications 2015, 10 (9)
Russo et al. Molecules 2018, 23, 2174
Serra et al. Nutrients 2021, 13, 999
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